If you get motion sick easily, you may be more comfortable if you take some sort of motion sickness drug before you fly. Note that you must take the drugs before you get sick; there is unfortunately nothing that I know of that will relieve motion sickness once it has started. My personal drug of choice is Dramamine, a readily-obtained over-the-counter medication. Unlike Bonine, another over-the-counter drug, it tends to make one drowsy. I feel that this is a benefit on a long plane ride! Another motion sickness treatment (usually used for boating) is Scopolamine patches. These patches go behind the ear, and usually have no noticeable side effects. I believe that in the USA, a prescription is required. Furthermore, there can be unpleasant side effects, such as dry mouth, blurry vision, and one other one that I forget. (Oh yeah - loss of memory.)
Motion sickness is caused in part by a discrepancy between what the eye sees and what the inner ear feels. (This is why the driver of a car gets sick much less frequently than a passenger: the driver is continuously watching the road, getting a good idea of what is coming next.) It may help to close your eyes the moment you start to consider thinking about getting airsick.
If you do come down with discomfort, one relatively easy but embarrassing way to feel better is to empty your stomach. 'Barf bags' are usually located in the pouch on the back of the seat in front of you. Frequently, using them reduces and/or eliminates the discomfort.
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